Methylprednisolone

Indications

Inflammatory disorders in adults; also licensed for infusion in children (non‑intramuscular)

Contraindications

Congestive heart failure; diabetes; diverticulitis; epilepsy; glaucoma; hypertension; hypothyroidism; infection; myasthenia gravis; herpes simplex eye infection; osteoporosis; peptic ulcer; psychiatric reactions; recent intestinal anastomoses; recent myocardial infarction; severe affective disorders (particularly if history of steroid-induced psychosis); thromboembolic disorders. Use during pregnancy and breastfeeding if benefit outweighs risk. Caution in renal or hepatic impairment | Potential side effects: Anxiety; changes in mood and behaviour; cataracts; cognitive impairment; Cushing’s syndrome; electrolyte imbalance; fatigue; fluid retention; gastrointestinal discomfort; headache; impaired healing; skin reactions; sleep disorders; weight increase hirsutism; hypertension; increased risk of infection; menstrual cycle irregularities; nausea; osteoporosis; peptic ulcer; psychotic disorder;

Preparations Available

Intramuscular injection

Quantity

Dose: Adults: 40–120mg initially (into gluteal muscle), then 40–120mg after 2–3 weeks if required; children: refer to BNFC

Sizes Available

1g powder and solvent for solution for injection vials £17.30, £17.30

Price

1g powder and solvent for solution for injection vials £17.30, £17.30

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